Shaanxi BLOOM Tech Co., Ltd. is one of the most experienced manufacturers and suppliers of 4-bromo-d-phenylalanine cas 62561-74-4 in China. Welcome to wholesale bulk high quality 4-bromo-d-phenylalanine cas 62561-74-4 for sale here from our factory. Good service and reasonable price are available.
4‑Bromo‑D‑phenylalanine typically exists in the form of white to almost‑white crystalline solids. It exhibits optical‑rotation properties and is capable of rotating polarized light. Apart from its application in the synthesis of peptide and protein‑based pharmaceuticals, it can also serve for preparing reagents used in peptide solid‑phase synthesis. As an experienced manufacturer of chiral amino‑acid intermediates, Bloomtechz delivers consistent‑quality 4‑Bromo‑D‑phenylalanine. Supported by our mature R&D system, complete batch‑wise quality reports and one‑on‑one technical support, we realize stable raw‑material supply for your research and development projects.

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C9H10BrNO2 |
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243 |
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244 |
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m/z |
243 (100.0%), 245 (97.3%), 244 (9.7%), 246 (9.5%) |
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C, 44.29; H, 4.13; Br, 32.74; N, 5.74; O, 13.11 |

4-Bromo-D-phenylalanine
It is a commonly used amino acid analogue that can be used to synthesize peptide and protein drugs. It has similar chemical properties and structure to natural amino acids, making it an effective substitute. By introducing 4-Bromo-D phenylalanine into peptide or protein drugs, the biological activity and pharmacokinetic properties of the drug can be improved, thereby improving its efficacy and reducing side effects.
4-Bromo-D phenylalanine is often used as a building block in the synthesis of peptide and protein drugs, and can be used to synthesize drugs with specific structures and functions. These drugs can be used to treat various diseases, such as cancer, neurological diseases, metabolic diseases, autoimmune diseases, etc. By introducing 4-Bromo-D phenylalanine into these drugs, their water solubility and stability can be improved, thereby improving the efficacy of the drug and reducing side effects.
2. Used to study protein structure:
4-Bromo-D phenylalanine can be used to study protein structure. Due to its chemical properties similar to natural amino acids, it can be used to prepare protein mutants to study the structural and functional relationships of proteins. By introducing 4-Bromo-D phenylalanine into proteins, the structure and properties of proteins can be altered, thereby affecting their biological function and activity. This technology has been widely applied in the study of the structure and function of various proteins.
In studying protein structure, 4-Bromo-D phenylalanine is often used as a marker that can be used to label specific sites in proteins. By introducing 4-Bromo-D phenylalanine into specific sites in proteins, the structure and kinetic processes of proteins can be studied. In addition, in studying protein structure, 4-Bromo-D phenylalanine can also be used to prepare antigens and antibodies for studying molecular recognition processes in immunology and biology.
3. Used for synthesizing fluorescent probes:
4‑Bromo‑D‑phenylalanine serves as a building block for the synthesis of fluorescent probes. Owing to its bromine substituent, fluorescent moieties can be incorporated to yield probes with intrinsic fluorescence. Such fluorescent probes are applicable for detecting small‑molecule analytes and proteins within biological systems, as well as for investigating biomolecular interactions and dynamic biological processes.
Fluorescent probes represent widely‑utilized tools in biological and biomedical research for investigating biological events in cells and tissues. Incorporation of 4‑Bromo‑D‑phenylalanine enables the fabrication of fluorescent signal probes with defined wavelength and intensity characteristics. Such probes permit the detection of target molecules and proteins within biological systems, facilitating research into their localization, intermolecular interactions, and dynamic behaviors. Furthermore, these fluorescent probes are applicable to cell imaging and tracing assays, supporting the characterization of cellular and tissue‑level biological processes.
4. Used for synthesizing non natural amino acid analogues:
4‑Bromo‑D‑phenylalanine can be employed for the synthesis of unnatural amino acid analogs. Benefiting from the reactive bromine substituent on its aromatic ring, it readily undergoes cross‑coupling and other chemical transformations. These structurally diversified compounds act as promising candidates for drug molecules and functional materials. They hold great potential for disease therapy, peptide drug modification, as well as the rational development of new high‑performance functional materials with tailored biological and physicochemical properties.
Unnatural amino acid analogues constitute an important research frontier in modern organic chemistry and advanced materials science. Incorporating 4‑Bromo‑D‑phenylalanine into such analogues affords compounds with tailored structures and functionalities. These molecules represent promising candidates across diverse domains including pharmaceuticals, catalysts, optoelectronic materials, and self‑assembled membranes. They find broad applications in disease therapy, catalytic chemical transformations, and the development of novel high‑performance materials.
5. Used for synthesizing pesticides and herbicides:
4-Bromo-D-phenylalanine can be used to synthesize pesticides and herbicides. It can be used as a block to synthesize circular structures in various pesticide and herbicide molecules. These pesticides and herbicides can be used to control plant diseases, pests, and weeds, improving crop yield and quality.
Pesticides and herbicides are one of the commonly used chemicals in agriculture, which can be used to control plant diseases, pests, and weeds, improve crop yield and quality.
Incorporation of 4‑Bromo‑D‑phenylalanine into pesticide and herbicide molecules can modulate their chemical properties, biological activities and pharmacological efficacy, enabling the development of more potent agrochemical agents. Furthermore, 4‑Bromo‑D‑phenylalanine can be utilized for the fabrication of insecticides and other agricultural chemicals, which suppress pest proliferation and growth so as to safeguard crop yields.


4‑Bromo‑D‑phenylalanine is a high-value chiral amino acid intermediate, widely applied in peptide synthesis, protein drug research and development, and peptide solid-phase synthesis reagent preparation. Its production requires precise stereoselective synthesis and stringent purification procedures, which are essential to guarantee excellent optical purity, low impurity content and stable batch consistency.
The mainstream production process adopts D-phenylalanine as the starting material. By precisely controlling temperature, pH value and feeding ratio, selective para-bromination is realized on the benzene ring,
effectively preventing over-bromination and isomer by-product formation. After the reaction, the system undergoes alkalization treatment, organic extraction, dehydration concentration and recrystallization to obtain crude products. Multiple rounds of fine purification and chiral resolution are carried out to remove residual raw materials, by-products and racemic impurities, ensuring complete stereoscopic structural integrity of the D-configuration.
Key indicators including HPLC purity, specific optical rotation, moisture content and residual solvents are monitored in real time throughout production. Solidified process parameters greatly reduce process errors and batch fluctuations,


enabling the final product to meet pharmaceutical-grade intermediate standards for lead compound screening and large-scale synthesis.The entire production and quality inspection system complies with ISO quality management specifications. Complete process records and test data are retained for each batch. Qualified documents such as batch COA and MSDS are available to support experimental traceability, internal review and project filing.
Leveraging mature chiral synthesis technology and refined purification systems, Bloomtechz consistently supplies high-purity 4‑Bromo‑D‑phenylalanine with stable optical activity. Adopting sealed, moisture-proof and light-shielding packaging together with standardized chemical logistics,
we ensure stable product quality during long-distance transportation and long-term storage, delivering reliable raw material support for pharmaceutical R&D and industrial synthesis.
As an active chiral amino acid intermediate, 4‑Bromo‑D‑phenylalanine requires standardized operation and storage to avoid quality deterioration and potential safety hazards. All laboratory operations must be performed in a fume hood with protective gloves and safety goggles. Direct skin contact, dust inhalation and accidental ingestion should be strictly avoided,


as the product may cause mild irritation to the skin, eyes and respiratory tract.In case of accidental contact, immediate flushing with sufficient clean water is required for emergency treatment.The product should be tightly sealed and stored in a dry, cool, dark and low-humidity environment. Long-term exposure to light, high temperature or humid air may cause oxidation, moisture absorption and racemization, resulting in decreased optical purity and increased impurities, which will adversely affect the accuracy of peptide synthesis and drug preparation. Residual materials should be resealed after each use to isolate air and moisture.
Classified as a conventional fine chemical intermediate, this product must be kept away from strong oxidants, strong acids and high-temperature heat sources during transportation to prevent abnormal chemical reactions. The whole delivery process follows professional chemical transportation standards to ensure intact packaging and stable performance.In practical synthetic applications, reaction conditions and reagent compatibility must be strictly controlled. Mixing with incompatible reagents is prohibited to avoid side reactions. Standardized operating procedures ensure personal experimental safety and maximize batch stability, enabling the product to deliver optimal performance in chiral synthesis and pharmaceutical research.



Chiral intermediates are extremely sensitive to trace impurities and configuration changes, which directly determine the success rate of downstream drug synthesis. Bloomtechz establishes exclusive quality control standards for chiral products, implementing full‑process monitoring of chiral resolution efficiency, residual isomer content and trace heavy metal indicators. Each batch undergoes strict HPLC chiral analysis and specific rotation testing to guarantee consistent stereochemical performance across different batches.
We eliminate common industry pain points such as fluctuating optical purity, hidden residual impurities and unstable reaction activity.Whether for laboratory small‑batch trial synthesis or continuous industrial scale‑up production, our products maintain highly consistent reaction performance,
effectively reducing customer experimental repetition rate and R&D costs.
Chiral intermediates are extremely sensitive to trace impurities and configuration changes, which directly determine the success rate of downstream drug synthesis. Bloomtechz establishes exclusive quality control standards for chiral products, implementing full‑process monitoring of chiral resolution efficiency, residual isomer content and trace heavy metal indicators.
Each batch undergoes strict HPLC chiral analysis and specific rotation testing to guarantee consistent stereochemical performance across different batches.
We eliminate common industry pain points such as fluctuating optical purity,hidden residual impurities and unstable reaction activity.

Whether for laboratory small‑batch trial synthesis or continuous industrial scale‑up production, our products maintain highly consistent reaction performance, effectively reducing customer experimental repetition rate and R&D costs.
[1] Turnbull, J. L., et al. Chemoenzymatic Synthesis of Optically Pure l- and d-Biarylalanines through Biocatalytic Asymmetric Amination and Palladium-Catalyzed Arylation[J].
[2] Liu, Y., Zhang, H. Halogen-Substituted Unnatural Amino Acids as Versatile Building Blocks for Fluorescent Probe Construction[J].
[3] Pollegioni, L., Servi, S. Unnatural Amino Acids: Methods and Protocols[M]. New York: Humana Press, 2012, 215-234.
[4] Wang, Q., Li, S. Site-Specific Incorporation of p-Bromophenylalanine Enantiomers for Peptide-Based Agrochemical and Pharmaceutical Lead Discovery[J].
[5] Hsieh, C., Chen, K. Expanding the Fluorescence Toolkit: Molecular Design, Synthesis and Biological Application of Unnatural Amino Acids[J].
Q1: What kinds of quality‑related documents can I get when ordering 4‑Bromo‑D‑phenylalanine?
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A: Bloomtechz provides complete batch‑dependent quality test reports, MSDS and enterprise qualification documents for every order. These materials support your laboratory testing traceability, internal project review and project filing. We also accept reasonable adjustments to document formats according to customer requirements.
Q2: Can you satisfy both small‑sample lab demands and large‑batch commercial procurement for chiral amino‑acid intermediates?
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A: Yes. Bloomtechz supports flexible procurement ranges from laboratory small‑scale sample evaluation to large‑volume commercial production. Multiple packaging specifications are available. Our sales team follows the whole order procedure and updates logistics progress in real‑time. Samples and bulk products are produced under identical quality‑control standards.
Q3: Can you support customized requirements for 4‑Bromo‑D‑phenylalanine?
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A: Bloomtechz is capable of supporting certain customized demands, such as special purity specifications, customized packaging forms and special drying requirements. You can put forward your detailed index requirements. Our technical department will carry out feasibility assessment, then give feedback on process feasibility, delivery cycle and corresponding quotation.
Q4: What is your core advantage compared with intermediate distributors?
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A: As the source manufacturer, Bloomtechz completes production, purification and quality inspection internally without intermediate links. We can flexibly respond to customer demands for different purity grades. Direct communication between technical teams avoids information delay or distortion often seen in multi‑level distribution channels.
Q5: What long‑term cooperative benefits can customers enjoy with Bloomtechz?
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A: Long‑term partnering customers with Bloomtechz can enjoy exclusive preferential policies, including stable priority production scheduling, shortened order delivery cycles, and regular product process upgrade notifications. Meanwhile, we provide exclusive one‑to‑one account manager service, customized procurement plans and flexible settlement terms, fully optimizing your long‑term raw material procurement efficiency and cost control.
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